SCHEMBL4649505

SCHEMBL4649505

Oc1ccccc1OC(Cl)C(Cl)(Cl)Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.43
TP53 P04637 2/20 0.43
CA1 P00915 1/20 0.43
TSHR P16473 1/20 0.43
MAPT P10636 4/20 0.41
LMNA P02545 3/20 0.41
GAA P10253 3/20 0.41
JAK2 O60674 1/20 0.41
ALDH1A1 P00352 5/20 0.35
KDM4E B2RXH2 2/20 0.35
CYP3A4 P08684 2/20 0.35
HPGD P15428 2/20 0.35
ALOX15 P16050 2/20 0.35
HSD17B10 Q99714 2/20 0.35
POLB P06746 2/20 0.35
NPC1 O15118 1/20 0.35
CA12 O43570 1/20 0.35
GMNN O75496 1/20 0.35
EGFR P00533 1/20 0.35
FYN P06241 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10417879 0.79 CA2 (0.50) CA2TP53CA1TSHRMAPT
SCHEMBL27365592 0.75 CA2 (0.52) CA2TP53CA1TSHRMAPT
SCHEMBL3920124 0.72 TSHR (0.43) CA2TP53CA1TSHRMAPT
SCHEMBL4649503 0.72 CA2 (0.43) CA2TP53CA1TSHRMAPT
SCHEMBL9427353 0.72 CA2 (0.52) CA2TP53CA1TSHRMAPT
SCHEMBL11771306 0.71 CA2 (0.52) CA2TP53CA1TSHRMAPT
SCHEMBL29737595 0.70 TP53 (0.56) CA2TP53CA1TSHRMAPT
SCHEMBL8747528 0.70 CA2 (0.56) CA2TP53CA1TSHRMAPT
SCHEMBL10842648 0.70 CA2 (0.50) CA2TP53CA1TSHRMAPT
SCHEMBL104203 0.70 TP53 (0.56) CA2TP53CA1TSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1056389-B1 BRAIDED SUTURE TYCO GROUP SARL (LU) 2008-09-03 EP disclosed
US-6203564-B1 ELIMINATING SURGICAL ?CHATTERING? WITH SUTURES MADE OF YARN FILAMENTS COMPOSED OF POLYESTER WITH INCREASED VISCOSITY; SURFACE ETCHED TO ENHANCE FEEL, HIGH TENSILE STRENGTH AND REDUCED FRAY UNITED STATES SURGICAL 2001-03-20 US disclosed
EP-1056389-A2 BRAIDED SUTURE Tyco Group S.A.R.L. (LU) 2000-12-06 EP disclosed
WO-2000008999-A9 BRAIDED SUTURE TYCO GROUP SARL (LU) 2000-08-10 WO disclosed
US-6060007-A DRY BLENDING A BIOCOMPATIBLE COLORANT WITH AN EXTRUDABLE NONBIOABSORBABLE THERMOPLASTIC RESIN TO FORM A UNIFORM BLEND OF COLORANT AND RESIN; EXTRUDING BY MELT SPINNING TO FORM FILAMENTS; DRAWING, THEN BRAIDING FILAMENTS INTO A SUTURE TYCO GROUP S.A.R.L. (LU) 2000-05-09 US disclosed
WO-2000008999-A2 BRAIDED SUTURE TYCO GROUP S.A.R.L. (US) 2000-02-24 WO disclosed