SCHEMBL4650499

SCHEMBL4650499

O=C(NC1C2CCC1CN(Cc1ccccc1)C2)C1Cc2ccccc2CN1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.51
MEN1 O00255 2/20 0.51
PRMT5 O14744 1/20 0.42
WDR77 Q9BQA1 1/20 0.42
OPRM1 P35372 1/20 0.42
OPRD1 P41143 1/20 0.42
OPRK1 P41145 1/20 0.42
SMYD3 Q9H7B4 1/20 0.41
POLB P06746 1/20 0.41
CXCR3 P49682 1/20 0.41
BLM P54132 1/20 0.39
GRIN2B Q13224 1/20 0.39
DRD2 P14416 1/20 0.39
DRD4 P21917 1/20 0.39
DRD3 P35462 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4649677 0.85 SIGMAR1 (0.46) DRD2DRD4
SCHEMBL14002084 0.82 SIGMAR1 (0.57) KMT2AMEN1POLBDRD2DRD4
SCHEMBL4649758 0.78 POLB (0.46) KMT2APOLBGRIN2BDRD2DRD4
SCHEMBL4913374 0.78 KMT2A (0.56) KMT2AMEN1PRMT5WDR77OPRM1
SCHEMBL4649174 0.77 TSHR (0.42) KMT2AMEN1
SCHEMBL2849565 0.77 GRIN2B (0.50) KMT2APOLBGRIN2BDRD2DRD4
SCHEMBL4648634 0.76 CHRM2 (0.40) KMT2AMEN1PRMT5WDR77OPRM1
SCHEMBL12586554 0.75 KMT2A (0.48) KMT2AMEN1PRMT5WDR77OPRM1
SCHEMBL12586571 0.75 KMT2A (0.48) KMT2AMEN1PRMT5WDR77OPRM1
SCHEMBL4649542 0.75 NAMPT (0.41) POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080255188-A1 Muscarinic Receptor Antagonists RANBAXY LABORATORIES LIMITED (IN) 2008-10-16 US claimed
EP-1904495-A2 MUSCARINIC RECEPTOR ANTAGONISTS Ranbaxy Laboratories Limited (IN) 2008-04-02 EP claimed
WO-2007007281-A2 MUSCARINIC RECEPTOR ANTAGONISTS RANBAXY LABORATORIES LIMITED (IN) 2007-01-18 WO claimed
US-20080255188-A1 Muscarinic Receptor Antagonists RANBAXY LABORATORIES LIMITED (IN) 2008-10-16 US disclosed
EP-1904495-A2 MUSCARINIC RECEPTOR ANTAGONISTS Ranbaxy Laboratories Limited (IN) 2008-04-02 EP disclosed
WO-2007007281-A2 MUSCARINIC RECEPTOR ANTAGONISTS RANBAXY LABORATORIES LIMITED (IN) 2007-01-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080255188-A1 Muscarinic Receptor Antagonists CHRM3, CHRM5, CHRM2 KMT2A 3036/4885MEN1 1581/4885PRMT5 794/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.