Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MDH2 | P40926 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650001 | 0.89 | CSNK2A2 (0.39) | DHODHCSNK2A2CSNK2BCSNK2A1CDK2 | |
| SCHEMBL4650011 | 0.88 | KDM4C (0.45) | KDM4CKDM5BCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL4649980 | 0.86 | CYP1A2 (0.43) | DAODHODHCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL4650110 | 0.81 | KDM5A (0.42) | KDM5AKDM4CKDM5BDAOCYP2C9 | |
| SCHEMBL4650790 | 0.81 | KDM5A (0.42) | KDM5AKDM5BDAOCSNK2A2CSNK2B | |
| SCHEMBL4650109 | 0.81 | CYP1A2 (0.46) | KDM5AKDM4CKDM5BCSNK2A2CSNK2B | |
| SCHEMBL4650035 | 0.80 | CSNK2A2 (0.43) | MAPK14CSNK2A2CSNK2BCSNK2A1ALDH1A1 | |
| SCHEMBL4650143 | 0.80 | CSNK2A2 (0.43) | CSNK2A2CSNK2BCSNK2A1ALDH1A1HPGD | |
| SCHEMBL4559012 | 0.79 | CHRM1 (0.43) | CSNK2A2CSNK2BCSNK2A1ALDH1A1HPGD | |
| SCHEMBL4649435 | 0.79 | CLEC4M (0.47) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | claimed |