Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992093 | 0.92 | GRM5 (0.77) | GRM5KDM4EHPGDALDH1A1POLB | |
| SCHEMBL990874 | 0.88 | GRM5 (1.00) | GRM5KDM4EHPGDALDH1A1POLB | |
| SCHEMBL990839 | 0.83 | GRM5 (1.00) | GRM5KDM4EHPGDALDH1A1POLB | |
| SCHEMBL22575077 | 0.83 | GRM5 (0.62) | GRM5KDM4EHPGDALDH1A1POLB | |
| SCHEMBL23909940 | 0.81 | GRM5 (0.59) | GRM5KDM4EHPGDALDH1A1POLB | |
| SCHEMBL20172444 | 0.78 | SMN1; SMN2 (0.54) | ALDH1A1RAB9ANAMPTSMN1; SMN2 | |
| SCHEMBL990918 | 0.77 | GRM5 (1.00) | GRM5KDM4EHPGDALDH1A1POLB | |
| SCHEMBL991635 | 0.77 | GRM5 (1.00) | GRM5KDM4EHPGDALDH1A1POLB | |
| SCHEMBL990190 | 0.77 | GRM5 (1.00) | GRM5KDM4EHPGDALDH1A1POLB | |
| SCHEMBL990134 | 0.74 | GRM5 (0.77) | GRM5KDM4EHPGDALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968579-A1 | PHARMACEUTICAL COMPOUNDS | Astex Therapeutics Limited (GB) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007077435-A1 | PHARMACEUTICAL COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-07-12 | — | — | WO | disclosed |