Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21258720 | 0.82 | HCAR3 (0.56) | MEN1KMT2ARAB9ANPC1L3MBTL1 | |
| SCHEMBL20172471 | 0.79 | NPC1 (0.47) | MEN1KMT2ARAB9ANPC1CYP11B1 | |
| SCHEMBL20172469 | 0.78 | KMT2A (0.62) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL31240789 | 0.78 | ABL1 (0.48) | MEN1KMT2ARAB9AALDH1A1LMNA | |
| SCHEMBL4650666 | 0.78 | GRM5 (0.77) | SMN1; SMN2RAB9ANAMPTALDH1A1 | |
| SCHEMBL28402729 | 0.77 | MAPT (0.57) | ADRA2AADRA2BADRA2CL3MBTL1MAPT | |
| SCHEMBL29501822 | 0.77 | MAPT (0.57) | ADRA2AADRA2BADRA2CL3MBTL1MAPT | |
| SCHEMBL3951733 | 0.77 | MEN1 (0.63) | MEN1KMT2ARAB9ANPC1KDR | |
| SCHEMBL4037525 | 0.77 | TSHR (0.61) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL22655182 | 0.76 | ALDH1A1 (0.66) | MEN1KMT2ARAB9ANPC1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106255688-B | Morpholine-pyridine derivate | 豪夫迈·罗氏有限公司 | 2019-11-08 | — | — | CN | disclosed |
| EP-3137459-B1 | MORPHOLIN-PYRIDINE DERIVATIVES HAVING AFFINITY TO THE TAAR1 RECEPTOR | HOFFMANN LA ROCHE (CH) | 2018-05-23 | — | — | EP | disclosed |