Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 2/20 | 0.31 |
| ▸ | PHGDH | O43175 | 1/20 | 0.31 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3046654 | 0.83 | NPC1 (0.30) | — | |
| SCHEMBL3759668 | 0.68 | SIGMAR1 (0.46) | CYP1A2CYP3A4 | |
| SCHEMBL3046813 | 0.67 | — | — | |
| SCHEMBL3046647 | 0.67 | — | — | |
| SCHEMBL25518887 | 0.67 | — | — | |
| SCHEMBL8508540 | 0.66 | CYP2B6 (0.37) | MEN1CYP1A2CYP3A4CYP2C19KMT2A | |
| SCHEMBL3051235 | 0.66 | HRH3 (0.42) | ALDH1A1CYP1A2 | |
| SCHEMBL3049699 | 0.64 | HRH3 (0.45) | ALDH1A1CYP1A2 | |
| SCHEMBL23336586 | 0.63 | CYP2B6 (0.38) | KMT2ACYP2B6 | |
| SCHEMBL22871678 | 0.63 | CYP2B6 (0.38) | KMT2ACYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098903-B1 | METHOD FOR PREPARING CYCLOSPORIN DERIVATIVES | AVENTIS PHARMA SA (FR) | 2008-09-03 | — | — | EP | disclosed |
| EP-0979244-B1 | NOVEL CYCLOSPORIN DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2005-03-02 | — | — | EP | disclosed |
| EP-1040121-B1 | NOVEL METHOD FOR PREPARING CYLOSPORIN DERIVATIVES | AVENTIS PHARMA (FR) | 2004-07-21 | — | — | EP | disclosed |
| EP-0948527-B1 | CYCLOSPORIN DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2002-06-05 | — | — | EP | disclosed |
| EP-1098903-A1 | NOVEL METHOD FOR PREPARING CYCLOSPORIN DERIVATIVES | Aventis Pharma S.A. (FR) | 2001-05-16 | — | — | EP | disclosed |
| WO-1999067280-A1 | NOVEL METHOD FOR PREPARING CYCLOSPORIN DERIVATIVES | AVENTIS PHARMA S.A. (FR) | 1999-12-29 | — | — | WO | disclosed |