Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FURIN | P09958 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CBFB | Q13951 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24233131 | 0.98 | FURIN (0.34) | FURINHTTKDM4EMEN1NPC1 | |
| Iodide SCHEMBL7222757 | 0.96 | KDM4E (0.36) | FURINHTTKDM4EMEN1NPC1 | |
| Bromide SCHEMBL4652704 | 0.75 | FURIN (0.33) | FURINHTTKDM4EMEN1NPC1 | |
| SCHEMBL1901414 | 0.72 | FURIN (0.34) | FURINHTTKDM4EMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL7222311 | 0.71 | FURIN (0.33) | FURINHTTKDM4EMEN1NPC1 | |
| Iodide SCHEMBL7218732 | 0.71 | KDM4E (0.36) | FURINHTTKDM4EMEN1NPC1 | |
| SCHEMBL13814467 | 0.71 | FURIN (0.33) | FURINHTTKDM4EMEN1NPC1 | |
| SCHEMBL2954136 | 0.68 | SMN1; SMN2 (0.33) | FURINHTTKDM4EMEN1NPC1 | |
| SCHEMBL24233140 | 0.68 | EEF2K (0.31) | — | |
| SCHEMBL24059054 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2003124-B1 | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III | CHATHAM BIOTEC LTD (CA) | 2015-02-25 | — | — | EP | disclosed |
| EP-2003124-A1 | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III | Chatham Biotec Ltd (CA) | 2008-12-17 | — | — | EP | disclosed |
| EP-1727810-B1 | SEMI-SYNTHESIS OF TAXANE INTERMEDIATES FROM 9-DIHYDRO-13-ACETYLBACCATIN III | CHATHAM BIOTEC LTD (CA) | 2008-10-01 | — | — | EP | disclosed |
| US-7202370-B2 | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III | CONOR MEDSYSTEMS, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| EP-1727810-A2 | SEMI-SYNTHESIS OF TAXANE INTERMEDIATES FROM 9-DIHYDRO-13-ACETYLBACCATIN III | Chatham Biotec Ltd. (CA) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005044811-A2 | SEMI-SYNTHESIS OF TAXANE INTERMEDIATES FROM 9-DIHYDRO-13-ACETYLBACCATIN III | PHYTOGEN LIFE SCIENCES INC. (CA) | 2005-05-19 | — | — | WO | disclosed |
| US-20050101789-A1 | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III | PHYTOGEN LIFE SCIENCES INC. (CA) | 2005-05-12 | — | — | US | disclosed |
| US-6632949-B2 | Difluoro-diamine methylene derivatives | MITSUI CHEMICALS, INC. (JP) | 2003-10-14 | — | — | US | disclosed |
| US-20030004348-A1 | Halogenating agents | SONODA HIROSHI (JP) | 2003-01-02 | — | — | US | disclosed |
| US-6458990-B1 | BIS(DIHYDROCARBYLAMINO)DIFLUOROMETHANE OR CYCLIC DERIVATIVES THEREOF; FORMING BY REACTING ALKALI METAL HALIDE WITH THE CORRESPONDING AMIDINIUM SALT; FLUORINATION OF ALCOHOLS, THIOPHENOLS, ALDEHYDES, AND KETONES | MITSUI CHEMICALS, INC. (JP) | 2002-10-01 | — | — | US | disclosed |
| EP-0949226-B1 | Process for the preparation of acetylene derivatives | MITSUI CHEMICALS INC (JP) | 2002-07-17 | — | — | EP | disclosed |
| US-20020042521-A1 | Nitrogen-based halogenating agents and process for preparing halogen-containing compounds | SONODA HIROSHI (JP) | 2002-04-11 | — | — | US | disclosed |
| US-6329529-B1 | FOR FLUORINATING OF ORGANIC COMPOUNDS, EFFICIENCY, POLLUTION CONTROL | MITSUI CHEMICALS, INC. (JP) | 2001-12-11 | — | — | US | disclosed |
| US-6127583-A | Process for preparing acetylene derivative from a ketone compound | MITSUI CHEMICALS, INC. (JP) | 2000-10-03 | — | — | US | disclosed |
| EP-0949226-A1 | Process for the preparation of acetylene derivatives | Mitsui Chemicals, Inc. (JP) | 1999-10-13 | — | — | EP | disclosed |
| EP-0895991-A2 | Halogenating agent | Mitsui Chemicals, Inc. (JP) | 1999-02-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101789-A1 | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III | CIAPIN1, TUBB3, ACACB | FURIN 646/4885HTT 3061/4885KDM4E 4697/4885 |
| US-20030004348-A1 | Halogenating agents | AFF1, NAF1, AFF2 | FURIN 3879/4885HTT 4060/4885KDM4E 3626/4885 |
| US-20020042521-A1 | Nitrogen-based halogenating agents and process for preparing halogen-containing compounds | AFF1, NAF1, CYP2F1 | FURIN 3687/4885HTT 4073/4885KDM4E 3197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.