Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL6538192 | 0.86 | FFAR3 (0.50) | FFAR3LCKFYNTP53 | |
| Acetic Acid SCHEMBL985917 | 0.85 | CA1 (0.38) | — | |
| Acetonitrile SCHEMBL3921006 | 0.80 | TSHR (0.35) | — | |
| Acetic Acid SCHEMBL4014382 | 0.80 | FFAR3 (0.58) | FFAR3LCKFYN | |
| Acetic Acid SCHEMBL211103 | 0.80 | — | — | |
| Acetic Acid SCHEMBL15658788 | 0.80 | FFAR3 (0.58) | FFAR3LCKFYN | |
| Acetic Acid SCHEMBL15657988 | 0.80 | FFAR3 (0.58) | FFAR3LCKFYN | |
| Acetic Acid SCHEMBL11256435 | 0.80 | FFAR3 (0.58) | FFAR3LCKFYN | |
| Acetic Acid SCHEMBL16004804 | 0.80 | FFAR3 (0.58) | FFAR3LCKFYN | |
| Acetic Acid SCHEMBL4986972 | 0.80 | FFAR3 (0.58) | FFAR3LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730773-B1 | POLYMERS OF POLYCYCLIC OLEFINS HAVING A POLYHEDRAL OLIGOSILSESQUIOXANE PENDANT GROUP AND USES THEREOF | PROMERUS LLC (US) | 2008-09-24 | — | — | EP | disclosed |
| EP-1730773-A1 | POLYMERS OF POLYCYCLIC OLEFINS HAVING A POLYHEDRAL OLIGOSILSESQUIOXANE PENDANT GROUP AND USES THEREOF | Promerus, LLC (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005081306-A1 | POLYMERS OF POLYCYCLIC OLEFINS HAVING A POLYHEDRAL OLIGOSILSESQUIOXANE PENDANT GROUP AND USES THEREOF | PROMERUS, LLC (US) | 2005-09-01 | — | — | WO | disclosed |
| US-20050192409-A1 | Polymers of polycyclic olefins having a polyhedral oligosilsesquioxane pendant group and uses thereof | PROMERUS, LLC | 2005-09-01 | — | — | US | disclosed |