Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3
The experimentally established mechanism targets of Carvedilol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 8/20 | 0.96 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.96 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.96 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.96 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.96 |
| ▸ | DRD2 | P14416 | 3/20 | 0.96 |
| ▸ | MAPT | P10636 | 2/20 | 0.96 |
| ▸ | TLR4 | O00206 | 2/20 | 0.96 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.96 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.96 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.96 |
| ▸ | MLNR | O43193 | 1/20 | 0.96 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.96 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.96 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.96 |
| ▸ | APP | P05067 | 1/20 | 0.96 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.96 |
| ▸ | HTR1A | P08908 | 1/20 | 0.96 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carvedilol SCHEMBL2949267 | 0.99 | ADRB2 (0.94) | ADRB2DRD2MAPTTLR4DNM1 | |
| Carvedilol SCHEMBL29744884 | 0.98 | ADRB2 (1.00) | ADRB2DRD2MAPTTLR4DNM1 | |
| Carvedilol SCHEMBL1560204 | 0.98 | ADRB2 (1.00) | ADRB2DRD2MAPTTLR4DNM1 | |
| Carvedilol SCHEMBL29370188 | 0.98 | ADRB2 (1.00) | ADRB2DRD2MAPTTLR4DNM1 | |
| (R)-Carvedilol SCHEMBL29744872 | 0.98 | ADRB2 (1.00) | ADRB2DRD2MAPTTLR4DNM1 | |
| Carvedilol SCHEMBL29687280 | 0.98 | ADRB2 (1.00) | ADRB2DRD2MAPTTLR4DNM1 | |
| Carvedilol SCHEMBL10082334 | 0.98 | ADRB2 (1.00) | ADRB2DRD2MAPTTLR4DNM1 | |
| (R)-Carvedilol SCHEMBL232110 | 0.98 | ADRB2 (1.00) | ADRB2DRD2MAPTTLR4DNM1 | |
| Carvedilol SCHEMBL1172788 | 0.98 | ADRB2 (1.00) | ADRB2DRD2MAPTTLR4DNM1 | |
| (R)-Carvedilol SCHEMBL29382761 | 0.98 | ADRB2 (1.00) | ADRB2DRD2MAPTTLR4DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112675139-B | Aspirin carvedilol tablet and preparation method thereof | 重庆康刻尔制药股份有限公司 | 2023-04-07 | — | — | CN | claimed |
| CN-112675139-A | Aspirin carvedilol tablet and preparation method thereof | 重庆康刻尔制药股份有限公司 | 2021-04-20 | — | — | CN | claimed |
| EP-1991527-A2 | POLYMORPHOUS FORMS OF CARVEDILOL PHOSPHATE | Teva Pharmaceutical Industries Ltd (IL) | 2008-11-19 | — | — | EP | claimed |
| WO-2008002683-A2 | POLYMORPHOUS FORMS OF CARVEDILOL PHOSPHATE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-01-03 | — | — | WO | claimed |
| CN-112675139-B | Aspirin carvedilol tablet and preparation method thereof | 重庆康刻尔制药股份有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-112675139-A | Aspirin carvedilol tablet and preparation method thereof | 重庆康刻尔制药股份有限公司 | 2021-04-20 | — | — | CN | disclosed |
| CN-103373952-B | New crystal forms of carvedilol sulfate | 江苏恒瑞医药股份有限公司 | 2017-02-08 | — | — | CN | disclosed |
| CN-106045900-A | Preparation method of carvedilol phosphate hemihydrate | 佛山市隆信医药科技有限公司 | 2016-10-26 | — | — | CN | disclosed |