Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLCO1B3 | Q9NPD5 | 4/20 | 1.00 |
| ▸ | SLCO1B1 | Q9Y6L6 | 4/20 | 1.00 |
| ▸ | SLCO2B1 | O94956 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | F2 | P00734 | 1/20 | 0.67 |
| ▸ | PLAU | P00749 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Silicristin A SCHEMBL22571311 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| Silicristin A SCHEMBL29977624 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| Silicristin SCHEMBL29388135 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| Silicristin A SCHEMBL971442 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| Silicristin B SCHEMBL29420864 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| Silicristin A SCHEMBL12871270 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| Silicristin A SCHEMBL10049339 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| Silicristin B SCHEMBL20152103 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| SCHEMBL17663663 | 0.96 | SLCO1B3 (0.92) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| SCHEMBL17663665 | 0.95 | SLCO1B3 (0.90) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569358-B2 | Use of silymarin and/or constituents thereof as skin or hair pigmentation promoters | GREENPHARMA (FR) | 2013-10-29 | — | — | US | disclosed |
| EP-1845935-B1 | USE OF SILYMARINE AND/OR THE CONSTITUENTS THEREOF AS PROMOTERS OF THE PIGMENTATION OF THE SKIN OR HAIR | GREENPHARMA SAS (FR) | 2008-11-19 | — | — | EP | disclosed |
| US-20080033037-A1 | Utilisation de la silymarine et/ou de ses constituants comme agents promoteur de la pigmentation de la peau ou des cheveux | GREENPHARMA (FR) | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080033037-A1 | Utilisation de la silymarine et/ou de ses constituants comme agents promoteur de la pigmentation de la peau ou des cheveux | TES, NISCH, STMN2 | SLCO1B3 2095/4885SLCO1B1 1854/4885SLCO2B1 1722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.