Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLCO1B3 | Q9NPD5 | 4/20 | 1.00 |
| ▸ | SLCO1B1 | Q9Y6L6 | 4/20 | 1.00 |
| ▸ | SLCO2B1 | O94956 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | F2 | P00734 | 1/20 | 0.67 |
| ▸ | PLAU | P00749 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Silicristin A SCHEMBL22571311 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| Silicristin A SCHEMBL29977624 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| Silicristin SCHEMBL29388135 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| Silicristin A SCHEMBL971442 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| Silicristin B SCHEMBL29420864 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| Silicristin A SCHEMBL12871270 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| Silicristin A SCHEMBL10049339 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| Silicristin A SCHEMBL4654076 | 1.00 | SLCO1B3 (1.00) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| SCHEMBL17663663 | 0.96 | SLCO1B3 (0.92) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 | |
| SCHEMBL17663665 | 0.95 | SLCO1B3 (0.90) | SLCO1B3SLCO1B1SLCO2B1MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10702568-B2 | Compositions containing silymarin and sulfoalkyl ether cyclodextrin and methods of using the same | CYDEX PHARMACEUTICALS, INC. (US) | 2020-07-07 | — | — | US | disclosed |
| US-20180133274-A1 | COMPOSITIONS CONTAINING SILYMARIN AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USING THE SAME | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2018-05-17 | — | — | US | disclosed |
| US-20180133274-A1 | COMPOSITIONS CONTAINING SILYMARIN AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USING THE SAME | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10702568-B2 | Compositions containing silymarin and sulfoalkyl ether cyclodextrin and methods of using the same | GYS2, SDCBP, PYGL | SLCO1B3 3765/4885SLCO1B1 3490/4885SLCO2B1 3833/4885 |
| US-20180133274-A1 | COMPOSITIONS CONTAINING SILYMARIN AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USING THE SAME | GYS2, SDCBP, PYGL | SLCO1B3 3765/4885SLCO1B1 3490/4885SLCO2B1 3833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.