Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.49 |
| ▸ | LMNA | P02545 | 7/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.49 |
| ▸ | USP2 | O75604 | 6/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 5/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CD38 | P28907 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4178262 | 0.78 | ALDH1A1 (0.47) | CLK4LMNACYP1A2CYP3A4HSD17B10 | |
| SCHEMBL4178264 | 0.78 | ALDH1A1 (0.47) | CLK4LMNACYP1A2CYP3A4HSD17B10 | |
| SCHEMBL4168742 | 0.75 | CD38 (0.49) | CLK4LMNACYP1A2CYP3A4HSD17B10 | |
| SCHEMBL4183976 | 0.75 | ALDH1A1 (0.55) | CLK4LMNACYP1A2CYP3A4HSD17B10 | |
| SCHEMBL4171466 | 0.73 | CYP1A2 (0.48) | CLK4LMNACYP1A2CYP3A4HSD17B10 | |
| Hydrochloric Acid SCHEMBL4182086 | 0.72 | CD38 (0.46) | CLK4LMNACYP1A2CYP3A4HSD17B10 | |
| SCHEMBL4176373 | 0.72 | ALDH1A1 (0.45) | CLK4LMNACYP1A2CYP3A4HSD17B10 | |
| SCHEMBL4183788 | 0.72 | CYP3A4 (0.52) | CLK4LMNACYP1A2CYP3A4HSD17B10 | |
| SCHEMBL4182093 | 0.72 | ALDH1A1 (0.54) | CLK4LMNACYP1A2CYP3A4HSD17B10 | |
| SCHEMBL4173676 | 0.71 | CLK4 (0.51) | CLK4LMNACYP1A2CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996562-A1 | SUBSTITUTED 4-AMINO-QUINAZOLINE DERIVATIVES AS REGULATORS OF METABOTROPIC GLUTAMATE RECEPTORS AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-12-03 | — | — | EP | claimed |
| WO-2007104560-A1 | SUBSTITUTED 4-AMINO-QUINAZOLINE DERIVATIVES AS REGULATORS OF METABOTROPIC GLUTAMATE RECEPTORS AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-09-20 | — | — | WO | claimed |