Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13948657 | 0.80 | HRH3 (0.42) | HRH3CYP2D6LMNACHRM2HTR1A | |
| SCHEMBL18610400 | 0.80 | HRH3 (0.42) | HRH3CYP2D6LMNACHRM2HTR1A | |
| SCHEMBL19200152 | 0.78 | ALDH1A1 (0.42) | HRH3CYP2D6LMNACHRM2HTR1A | |
| SCHEMBL3983973 | 0.77 | CYP2D6 (0.41) | HRH3CYP2D6LMNAL3MBTL1SIGMAR1 | |
| SCHEMBL11972631 | 0.77 | CYP2D6 (0.41) | HRH3CYP2D6LMNAL3MBTL1SIGMAR1 | |
| SCHEMBL18403180 | 0.77 | CARM1 (0.39) | HRH3CYP2D6LMNACHRM2HTR1A | |
| SCHEMBL2189098 | 0.77 | HRH3 (0.44) | HRH3MAPTCYP2D6LMNACHRM2 | |
| SCHEMBL2188091 | 0.77 | HRH3 (0.44) | HRH3MAPTCYP2D6LMNACHRM2 | |
| SCHEMBL24277911 | 0.77 | HRH3 (0.48) | HRH3MAPTCYP2D6LMNACHRM2 | |
| SCHEMBL10032106 | 0.77 | HRH3 (0.48) | HRH3MAPTCYP2D6LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991528-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | Siena Biotech S.p.A. (IT) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007098826-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | SIENA BIOTECH S.P.A. (IT) | 2007-09-07 | — | — | WO | disclosed |