Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 2/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | FYN | P06241 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | USP7 | Q93009 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3225405 | 0.84 | SMN1; SMN2 (0.50) | PARP1DHODHALDH1A1BRD4RAB9A | |
| SCHEMBL5605821 | 0.82 | PI4K2A (0.57) | PI4K2APARP1DHODHNQO2CHEK2 | |
| SCHEMBL27799605 | 0.81 | NQO2 (0.45) | PI4K2ANQO2ALDH1A1BRD4NPC1 | |
| SCHEMBL4631064 | 0.80 | TLR8 (0.45) | PARP1DHODHALDH1A1BRD4RAB9A | |
| SCHEMBL16719394 | 0.78 | IKBKB (0.44) | PARP1FYNHSD17B1HSD17B2 | |
| SCHEMBL3165969 | 0.78 | BAZ2B (0.44) | PARP1DHODHBRD4NPC1RAB9A | |
| SCHEMBL4916850 | 0.77 | PARP1 (0.49) | PARP1CHEK2ALDH1A1HSD17B10KDM4E | |
| SCHEMBL4638595 | 0.77 | HPGDS (0.46) | PARP1CHEK2FYN | |
| SCHEMBL731180 | 0.76 | NQO2 (0.54) | NQO2ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL694904 | 0.76 | NQO2 (0.56) | NQO2ALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991528-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | Siena Biotech S.p.A. (IT) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007098826-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | SIENA BIOTECH S.P.A. (IT) | 2007-09-07 | — | — | WO | disclosed |