Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3951805 | 0.94 | SLC6A2 (0.54) | SLC6A2SLC6A4EPHX2HRH3MEN1 | |
| SCHEMBL27662478 | 0.90 | SLC6A2 (0.49) | SLC6A2SLC6A4EPHX2HRH3KCNA5 | |
| SCHEMBL3960427 | 0.88 | SLC6A2 (0.56) | SLC6A2SLC6A4EPHX2HRH3KMT2A | |
| SCHEMBL3955967 | 0.87 | GPR119 (0.49) | SLC6A2SLC6A4HRH3MEN1KMT2A | |
| SCHEMBL3955520 | 0.84 | GPR119 (0.50) | SLC6A2SLC6A4EPHX2HRH3MEN1 | |
| SCHEMBL3956027 | 0.83 | POLB (0.52) | SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL3952423 | 0.83 | SLC6A2 (0.45) | SLC6A2SLC6A4EPHX2MEN1KMT2A | |
| SCHEMBL3960371 | 0.83 | SLC6A2 (0.50) | SLC6A2SLC6A4EPHX2ALDH1A1 | |
| SCHEMBL3955395 | 0.82 | SLC6A2 (0.46) | SLC6A2SLC6A4EPHX2 | |
| SCHEMBL3955391 | 0.82 | SLC6A2 (0.46) | SLC6A2SLC6A4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7419980-B2 | Fused-aryl and heteroaryl derivatives and methods of their use | WYETH (US) | 2008-09-02 | — | — | US | disclosed |
| EP-1687288-B1 | SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | WYETH CORP (US) | 2008-01-16 | — | — | EP | disclosed |
| CN-1972920-A | Arylalkyl piperazine derivatives for the treatment of conditions ameliorated by monoamine reuptake including vasomotor symptoms | WYETH CORP (US) | 2007-05-30 | — | — | CN | disclosed |
| CN-1894226-A | Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use | WYETH CORP (US) | 2007-01-10 | — | — | CN | disclosed |