Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 2/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4655291 | 0.93 | ECE1 (0.49) | ECE1TRPV1NOTUMMAPTRORC | |
| SCHEMBL4656220 | 0.85 | ECE1 (0.59) | ECE1CNR1CNR2NOTUMMAPT | |
| SCHEMBL4655331 | 0.83 | MAOB (0.51) | ECE1NOTUMMAPTMAOBKDM4E | |
| SCHEMBL4656319 | 0.83 | ECE1 (0.50) | ECE1NOTUMMAPTMAOBKDM4E | |
| SCHEMBL4655285 | 0.83 | ECE1 (0.53) | ECE1CNR1CNR2NOTUMMAPT | |
| SCHEMBL4656109 | 0.83 | MAPT (0.51) | ECE1NOTUMMAPTMAOBKDM4E | |
| SCHEMBL4655284 | 0.82 | ECE1 (0.48) | ECE1NOTUMMAPTMAOBKDM4E | |
| SCHEMBL3571160 | 0.82 | ECE1 (0.48) | ECE1CNR1CNR2NOTUMMAPT | |
| SCHEMBL4655289 | 0.82 | ECE1 (0.53) | ECE1TRPV1NOTUMMAPTMAOB | |
| SCHEMBL4655301 | 0.82 | ECE1 (0.48) | ECE1CNR1CNR2NOTUMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101010297-B | N- (1H-indolyl) -1H-indole-2-carboxamide derivatives, their preparation and their pharmaceutical use | SANOFI AVENTIS | 2011-07-27 | — | — | CN | claimed |
| EP-1776340-B1 | N-(1H-INDOLYL)-H-INDOLE-2-CARB0XAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | SANOFI AVENTIS (FR) | 2008-12-03 | — | — | EP | claimed |