Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 8/20 | 0.58 |
| ▸ | PLA2G5 | P39877 | 8/20 | 0.58 |
| ▸ | PLA2G10 | O15496 | 7/20 | 0.58 |
| ▸ | PPARG | P37231 | 3/20 | 0.48 |
| ▸ | PTGES | O14684 | 2/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3575743 | 0.88 | PLA2G10 (0.54) | PLA2G2APLA2G5PLA2G10PPARGNOTUM | |
| SCHEMBL3573071 | 0.81 | PLA2G10 (0.48) | PLA2G2APLA2G5PLA2G10PPARGNOTUM | |
| SCHEMBL4913430 | 0.80 | PTGES (0.58) | PLA2G2APLA2G5PLA2G10PPARGPTGES | |
| SCHEMBL30805871 | 0.77 | PLA2G10 (0.71) | PLA2G2APLA2G5PLA2G10 | |
| SCHEMBL30805932 | 0.77 | PLA2G10 (0.71) | PLA2G2APLA2G5PLA2G10 | |
| SCHEMBL4926021 | 0.76 | PTGES (0.61) | PLA2G2APLA2G5PLA2G10PPARGPTGES | |
| SCHEMBL10253811 | 0.74 | KDM4E (0.69) | ALDH1A1NTRK1GFERKDM4EHPGD | |
| SCHEMBL3575240 | 0.74 | PTGES (0.76) | PLA2G2APLA2G5PLA2G10PTGESGCGR | |
| SCHEMBL3568117 | 0.73 | PTGES (0.58) | PLA2G2APLA2G5PLA2G10PPARGPTGES | |
| SCHEMBL4925957 | 0.73 | GFER (0.44) | PLA2G2APLA2G5PLA2G10PPARGPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776340-B1 | N-(1H-INDOLYL)-H-INDOLE-2-CARB0XAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | SANOFI AVENTIS (FR) | 2008-12-03 | — | — | EP | disclosed |
| EP-1776340-A1 | N-(1H-INDOLYL)-H-INDOLE-2-CARB0XAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | Sanofi-Aventis (FR) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006024776-A1 | N(1 H-INDOLYL)-1 H-INDOLE-2-CARB0XAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | SANOFI-AVENTIS (FR) | 2006-03-09 | — | — | WO | disclosed |