Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 15/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990824 | 1.00 | GRM5 (0.48) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL992253 | 1.00 | GRM5 (0.48) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL990340 | 0.91 | L3MBTL1 (0.59) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL990772 | 0.90 | GRM5 (0.60) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL3799474 | 0.90 | GRM5 (0.47) | GRM5L3MBTL1NPC1RAB9A | |
| 2-Picolinic Acid SCHEMBL3631655 | 0.89 | GRM5 (0.50) | GRM5L3MBTL1 | |
| SCHEMBL2818567 | 0.88 | L3MBTL1 (0.47) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL992266 | 0.87 | L3MBTL1 (0.46) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL990869 | 0.87 | GRM5 (0.48) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL990083 | 0.87 | L3MBTL1 (0.47) | GRM5L3MBTL1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877365-A1 | ACETYLENE DERIVATIVES | Novartis AG (CH) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006114262-A1 | ACETYLENE DERIVATIVES | NOVARTIS AG (CH) | 2006-11-02 | — | — | WO | disclosed |