Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 6/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | BRAF | P15056 | 2/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.57 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.57 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.52 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4655710 | 1.00 | ALDH1A1 (0.61) | ALDH1A1CSF1RCYP2C9BRAFMAPK14 | |
| SCHEMBL4655771 | 0.85 | ALDH1A1 (0.77) | ALDH1A1BTKPTGS1MEN1HTT | |
| SCHEMBL4655770 | 0.85 | ALDH1A1 (0.77) | ALDH1A1BTKPTGS1MEN1HTT | |
| SCHEMBL2497820 | 0.81 | CSF1R (0.70) | CSF1RCYP2C9BRAFMAPK14JAK2 | |
| SCHEMBL14468045 | 0.78 | MEN1 (0.68) | CSF1RCYP2C9BRAFMAPK14PTGS1 | |
| SCHEMBL99941 | 0.77 | ALDH1A1 (1.00) | ALDH1A1HTTRAB9AMAPTLMNA | |
| SCHEMBL99942 | 0.77 | ALDH1A1 (1.00) | ALDH1A1HTTRAB9AMAPTLMNA | |
| SCHEMBL14286496 | 0.76 | CSF1R (0.75) | CSF1RCYP2C9BRAFMAPK14JAK2 | |
| SCHEMBL2495506 | 0.76 | MAPT (0.61) | CSF1RCYP2C9BRAFMAPK14JAK2 | |
| SCHEMBL2950273 | 0.76 | CSF1R (0.81) | CSF1RCYP2C9BRAFMAPK14JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996594-A2 | PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007109093-A2 | PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |
| US-20070219186-A1 | Pyrazolo[1,5-A]pyrimidine derivatives and methods of use thereof | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219186-A1 | Pyrazolo[1,5-A]pyrimidine derivatives and methods of use thereof | DPYD, TYMP, TYMS | ALDH1A1 253/4885CSF1R 3829/4885CYP2C9 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.