Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 14/20 | 0.49 |
| ▸ | AURKA | O14965 | 10/20 | 0.49 |
| ▸ | TPX2 | Q9ULW0 | 7/20 | 0.49 |
| ▸ | TEK | Q02763 | 10/20 | 0.47 |
| ▸ | KDR | P35968 | 8/20 | 0.47 |
| ▸ | LCK | P06239 | 4/20 | 0.47 |
| ▸ | YES1 | P07947 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL973141 | 0.84 | AURKB (0.57) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL973140 | 0.79 | AURKB (0.60) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL1265702 | 0.77 | AURKB (0.68) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL5263953 | 0.75 | AURKB (0.59) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL580385 | 0.75 | TEK (0.60) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL581511 | 0.75 | TEK (0.60) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL1265359 | 0.74 | AURKB (0.51) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL974857 | 0.74 | AURKB (0.64) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL975890 | 0.73 | AURKB (0.57) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL975891 | 0.73 | AURKB (0.57) | AURKBAURKATPX2TEKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994030-A1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | Amgen Inc. (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007100646-A1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | AMGEN INC. (US) | 2007-09-07 | — | — | WO | disclosed |