⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1128378 | 1.00 | — | — | |
| SCHEMBL9203626 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL27846509 | 0.98 | OR51E2 (0.41) | — | |
| Hydrochloric Acid SCHEMBL26627502 | 0.98 | OR51E2 (0.41) | — | |
| SCHEMBL28599148 | 0.93 | CRBN (0.44) | — | |
| SCHEMBL4992808 | 0.91 | FKBP5 (0.43) | — | |
| SCHEMBL4995896 | 0.86 | — | — | |
| SCHEMBL4988016 | 0.86 | — | — | |
| SCHEMBL31681153 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL9731033 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250276979-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | GILEAD SCIENCES, INC. | 2025-09-04 | — | — | US | disclosed |
| US-20110190488-A1 | Methods of Making Cyclic Amide Monomers and Related Derivatives | Amyris, Inc. | 2011-08-04 | — | — | US | disclosed |
| US-20110190488-A1 | Methods of Making Cyclic Amide Monomers and Related Derivatives | Amyris, Inc. | 2011-08-04 | — | — | US | disclosed |
| EP-1430031-B1 | KINETIC RESOLUTION OF A INTERMEDIATE USEFUL IN THE PRODUCTION OF BENAZEPRIL AND ANALOGUES THEREOF | SCINOPHARM TAIWAN LTD (TW) | 2008-12-03 | — | — | EP | disclosed |
| US-7390801-B2 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds | ATHENA NEUROSCIENCES, INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-20070203108-A1 | Alzheimer's disease; 5-{N'-(4-thianaphthenacetyl)-L-alaninyl}-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one | THORSETT EUGENE D | 2007-08-30 | — | — | US | disclosed |
| US-7153847-B2 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds | ATHENA NEUROSCIENCES, INC. (US) | 2006-12-26 | — | — | US | disclosed |
| US-20060079499-A1 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds | WU JING | 2006-04-13 | — | — | US | disclosed |
| US-20050272666-A1 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds | WU JING | 2005-12-08 | — | — | US | disclosed |
| US-6951854-B1 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds | ATHENA NEUROSCIENCES, INC. (US) | 2005-10-04 | — | — | US | disclosed |
| EP-0518943-A1 | MERCAPTOACYL AMINOLACTAM ENDOPEPTIDASE INHIBITORS | SCHERING CORPORATION (US) | 1992-12-23 | — | — | EP | disclosed |
| US-5166150-A | Cognition activators | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1992-11-24 | — | — | US | disclosed |
| US-5155102-A | Cognition activators, analgesics | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1992-10-13 | — | — | US | disclosed |
| EP-0462949-A1 | 1-alkyl-3-(acylamino)-epsilon-caprolactames as enhancers of learning and memory and pharmaceutical compositions containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1991-12-27 | — | — | EP | disclosed |
| EP-0462948-A2 | Pharmaceutical compositions comprising 3-amino-epsilon-caprolactames for enhancing learning and memory | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1991-12-27 | — | — | EP | disclosed |
| US-5075302-A | Treating hypertension, congestive heart failure | SCHERING CORPORATION (US) | 1991-12-24 | — | — | US | disclosed |
| WO-1991013870-A1 | MERCAPTOACYL AMINOLACTAM ENDOPEPTIDASE INHIBITORS | SCHERING CORPORATION (US) | 1991-09-19 | — | — | WO | disclosed |
| EP-0119955-B1 | 3-(5-AMINOPENTYL)-AMINO-1-BENZAZEPIN-2-ONE-1-ALCANOIC ACIDS, PROCESS FOR THEIR PREPARATION, THEIR PHARMACEUTICAL PREPARATION AS WELL AS THEIR THERAPEUTIC USE | CIBA-GEIGY AG (CH) | 1989-12-13 | — | — | EP | disclosed |
| US-4600534-A | Process and intermediates for manufacture of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid | CIBA-GEIGY CORPORATION (US) | 1986-07-15 | — | — | US | disclosed |
| EP-0119955-A2 | 3-(5-Aminopentyl)-amino-1-benzazepin-2-one-1-alcanoic acids, process for their preparation, their pharmaceutical preparation as well as their therapeutic use | CIBA-GEIGY AG (CH) | 1984-09-26 | — | — | EP | disclosed |