Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 0.67 |
| ▸ | AXL | P30530 | 1/20 | 0.67 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.67 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.67 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196239 | 0.80 | CYP19A1 (1.00) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL30098510 | 0.80 | CYP19A1 (0.69) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL23924237 | 0.80 | CYP19A1 (0.69) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL128811 | 0.80 | CYP19A1 (0.69) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL1807468 | 0.79 | CYP19A1 (0.67) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| Bromide SCHEMBL15689048 | 0.79 | CYP19A1 (0.67) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL9571662 | 0.79 | CYP19A1 (0.67) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL9090840 | 0.78 | CYP19A1 (0.61) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL17014786 | 0.77 | CYP19A1 (1.00) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL30128572 | 0.77 | CYP19A1 (1.00) | CYP19A1AXLPBRM1MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996565-A2 | SUBSTITUTED AMINOTHIAZOLE DERIVATIVES WITH ANTI-HCV ACTIVITY | Achillion Pharmaceuticals, Inc. (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007103550-A2 | SUBSTITUTED AMINOTHIAZOLE DERIVATIVES WITH ANTI-HCV ACTIVITY | ACHILLION PHARMACEUTICALS, INC. (US) | 2007-09-13 | — | — | WO | disclosed |