Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.60 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.54 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.52 |
| ▸ | ERN1 | O75460 | 1/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 5/20 | 0.48 |
| ▸ | ATRIP | Q8WXE1 | 3/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4655702 | 0.83 | PDE10A (0.45) | PDE10ATLR8TLR7MEN1KMT2A | |
| SCHEMBL182583 | 0.77 | GAK (0.60) | PDE10AMAP4K1ERN1TLR8TLR7 | |
| SCHEMBL5480778 | 0.75 | PDE10A (1.00) | PDE10AMAP4K1 | |
| SCHEMBL4655563 | 0.74 | MEN1 (0.55) | PDE10AMEN1KMT2A | |
| SCHEMBL31216889 | 0.74 | PDE5A (0.56) | PDE10AZAP70MAP4K1ERN1TLR8 | |
| SCHEMBL4741794 | 0.72 | PDPK1 (0.58) | PDE10AZAP70 | |
| SCHEMBL2460475 | 0.72 | MEN1 (0.66) | PDE10AMEN1KMT2A | |
| SCHEMBL12963816 | 0.72 | PDE10A (0.62) | PDE10AZAP70MAP4K1ERN1TLR8 | |
| Hydrochloric Acid SCHEMBL1022954 | 0.71 | MEN1 (0.64) | PDE10AMEN1KMT2A | |
| SCHEMBL3951601 | 0.71 | PDE10A (0.59) | PDE10AZAP70MAP4K1ERN1TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996574-A1 | QUINOLINE AND ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | Amgen Inc. (US) | 2008-12-03 | — | — | EP | disclosed |
| US-20070299067-A1 | Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors | AMGEN INC. | 2007-12-27 | — | — | US | disclosed |
| US-20070299067-A1 | Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors | AMGEN INC. | 2007-12-27 | — | — | US | disclosed |
| US-20070299067-A1 | Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors | AMGEN INC. | 2007-12-27 | — | — | US | disclosed |
| WO-2007103554-A1 | QUINOLINE AND ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299067-A1 | Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors | PDE12, PDE10A, PDE4A | PDE10A 2/4885ZAP70 1134/4885MAP4K1 1653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.