Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NMBR | P28336 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 3/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348722 | 0.76 | SYK (0.48) | SYKNQO2MAPTTRPM8IDO1 | |
| SCHEMBL3348717 | 0.76 | SYK (0.48) | SYKNQO2MAPTTRPM8IDO1 | |
| SCHEMBL6746741 | 0.74 | LMNA (0.61) | MAPTNMBRIDO1KMT2AL3MBTL1 | |
| SCHEMBL6924623 | 0.73 | SYK (0.54) | SYKNQO2MAPTIDO1KMT2A | |
| SCHEMBL14561127 | 0.72 | SYK (0.61) | SYKMAPTCA1CA2IDO1 | |
| SCHEMBL3346820 | 0.72 | SYK (0.41) | SYKNQO2MAPTIDO1KMT2A | |
| SCHEMBL30063239 | 0.72 | SYK (0.58) | SYKMAPTTRPM8KMT2AALDH1A1 | |
| SCHEMBL21890682 | 0.72 | SYK (0.58) | SYKMAPTTRPM8KMT2AALDH1A1 | |
| SCHEMBL3343891 | 0.72 | SYK (0.53) | SYKMAPTTRPM8IDO1KMT2A | |
| SCHEMBL14275188 | 0.71 | SYK (0.57) | SYKTRPM8ALDH1A1CTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996202-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007104933-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | disclosed |