Cytosine

Cytosine

SCHEMBL4657334

Nc1cc[nH]c(=O)n1.Nc1cc[nH]c(=O)n1

nearest known ligand 0.44

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 1/20 0.44
TSHR P16473 1/20 0.36
JAK2 O60674 1/20 0.36
RPS6KA3 P51812 1/20 0.36
MELK Q14680 1/20 0.36
STK24 Q9Y6E0 1/20 0.36
ADORA2A P29274 4/20 0.36
ADORA1 P30542 4/20 0.36
AURKA O14965 1/20 0.34
AURKB Q96GD4 1/20 0.34
INCENP Q9NQS7 1/20 0.34
MAPT P10636 2/20 0.34
PARP1 P09874 3/20 0.33
RECQL P46063 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
CYP3A4 P08684 1/20 0.33
BLM P54132 1/20 0.33
ELANE P08246 1/20 0.32
AXL P30530 1/20 0.32
NUDT1 P36639 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cytosine SCHEMBL1330400 1.00
Cytosine SCHEMBL4059 1.00
Cytosine SCHEMBL1330710 1.00
Cytosine SCHEMBL19692377 0.98
Cytosine SCHEMBL2406920 0.98
Cytosine SCHEMBL4065266 0.98
Cytosine SCHEMBL10623341 0.98
Cytosine SCHEMBL21772310 0.98 DYRK1A (0.42) DYRK1ATSHRJAK2RPS6KA3MELK
Cytosine SCHEMBL20212017 0.98
Cytosine SCHEMBL4492966 0.98

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240229151-A9 COMPOSITIONS AND METHODS FOR MAKING AND USING AN IMMORTALIZED LIBRARY HARBINGER HEALTH, INC. 2024-07-11 US disclosed
CN-118098345-A Chromosome aneuploidy detection method, device, equipment and storage medium 深圳市真迈生物科技有限公司 2024-05-28 CN disclosed
US-20240132970-A1 COMPOSITIONS AND METHODS FOR MAKING AND USING AN IMMORTALIZED LIBRARY FLAGSHIP PIONEERING INNOVATIONS VI LLC (US) 2024-04-25 US disclosed
WO-2023147568-A2 COMPOSITIONS AND METHODS FOR MAKING AND USING AN IMMORTALIZED LIBRARY FLAGSHIP PIONEERING INNOVATIONS VI, LLC (US) 2023-08-03 WO disclosed
US-20230190709-A1 METHODS AND USES OF MICROBIOME COMPOSITIONS, COMPONENTS, OR METABOLITES FOR TREATING VAGUS NERVE ASSOCIATED DISEASES, DISORDERS, AND CONDITIONS MarvelBiome, Inc. (US) 2023-06-22 US disclosed
CN-115340478-A Schiff base ligand and preparation method and application of polynuclear rare earth complex thereof 温州医科大学 2022-11-15 CN disclosed
CN-115266662-A Hyperspectral sequencing method and system and gene sequencer 深圳赛陆医疗科技有限公司 2022-11-01 CN disclosed
US-20190214145-A1 Method and systems for creating and screening patient metabolite profile to diagnose current medical condition, diagnose current treatment state and recommend new treatment regimen KUREK ITZHAK (US) 2019-07-11 US disclosed
EP-3186231-A1 PROCESS FOR PRODUCING FLUOROCYTOSINE AND FLUOROCYTOSINE DERIVATIVES University of Durham (GB) 2017-07-05 EP disclosed
CN-104316621-B Method for measuring total nucleotide in protein products 上海征泰饲料有限公司 2017-01-11 CN disclosed
CN-104520437-B A kind of chromosomal aneuploidy detection method and device 深圳华大基因股份有限公司 2016-09-14 CN disclosed
WO-2016030662-A1 PROCESS FOR PRODUCING FLUOROCYTOSINE AND FLUOROCYTOSINE DERIVATIVES UNIVERSITY OF DURHAM (GB) 2016-03-03 WO disclosed
CN-104043126-A Modulation of axon degeneration GENENTECH INC 2014-09-17 CN disclosed
CN-102573855-A Modulation of axonal degeneration HOFFMANN LA ROCHE 2012-07-11 CN disclosed
EP-1747276-B1 CAROTENOID BIOSYNTHESIS INHIBITOR RESISTANCE GENES AND METHODS OF USE IN PLANTS BASF PLANT SCIENCE GMBH (DE) 2008-12-10 EP disclosed
EP-1747276-A2 CAROTENOID BIOSYNTHESIS INHIBITOR RESISTANCE GENES AND METHODS OF USE IN PLANTS BASF Plant Science GmbH (DE) 2007-01-31 EP disclosed
WO-2005111218-A2 CAROTENOID BIOSYNTHESIS INHIBITOR RESISTANCE GENES AND METHODS OF USE IN PLANTS BASF PLANT SCIENCE GMBH (DE) 2005-11-24 WO disclosed
EP-1005478-A1 RIBONUCLEOSIDE-DERIVATIVE AND METHOD FOR PREPARING THE SAME Pitsch, Stefan (CH) 2000-06-07 EP disclosed
WO-1999009044-A1 RIBONUCLEOSIDE-DERIVATIVE AND METHOD FOR PREPARING THE SAME PITSCH STEFAN (CH) 1999-02-25 WO disclosed
US-5698583-A MIXING THE SOLUTION OF ATLEAST ONE OLIGOELEMENT, SELECTED FROM SODIUM SELENITE, MAGNESIUM /MANGANESE/AND ZINC CHLORIDE, COBALT, CERIUM, MOLYBDENUM AND SILICON WITH BUFFERED SOLUTION OF PHOSPHOLIPASE A2; USED FOR IMMUNOTHERAPY CRESCENTI ERNESTO J V (AR) 1997-12-16 US disclosed