Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.58 |
| ▸ | PIM1 | P11309 | 2/20 | 0.58 |
| ▸ | BRAF | P15056 | 12/20 | 0.54 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.53 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4657297 | 0.89 | BRAF (0.69) | GSK3AEPHA2MAPK13PIM1BRAF | |
| SCHEMBL4658254 | 0.83 | MAPK13 (0.66) | GSK3AEPHA2MAPK13PIM1BRAF | |
| SCHEMBL5819844 | 0.82 | CDKN1A (0.76) | GSK3AEPHA2MAPK13PIM1BRAF | |
| SCHEMBL5622149 | 0.82 | MEN1 (0.42) | GSK3AEPHA2MAPK13PIM1BRAF | |
| SCHEMBL5623504 | 0.81 | BRAF (0.69) | GSK3AEPHA2MAPK13PIM1BRAF | |
| SCHEMBL4657114 | 0.81 | BRAF (0.67) | GSK3AEPHA2MAPK13PIM1BRAF | |
| SCHEMBL5808894 | 0.78 | CDKN1A (0.79) | GSK3AEPHA2MAPK13PIM1BRAF | |
| SCHEMBL5807757 | 0.78 | CDKN1A (0.72) | GSK3AEPHA2MAPK13PIM1BRAF | |
| SCHEMBL4656024 | 0.77 | BRAF (0.81) | GSK3AEPHA2MAPK13PIM1BRAF | |
| SCHEMBL3176935 | 0.77 | TLR8 (0.82) | GSK3AEPHA2MAPK13PIM1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996594-A2 | PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-12-03 | — | — | EP | claimed |
| WO-2007109093-A2 | PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | WYETH (US) | 2007-09-27 | — | — | WO | claimed |