Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.66 |
| ▸ | PIM1 | P11309 | 2/20 | 0.66 |
| ▸ | BRAF | P15056 | 13/20 | 0.65 |
| ▸ | GSK3A | P49840 | 2/20 | 0.63 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.63 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.59 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.59 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.58 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.58 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.56 |
| ▸ | AKT1 | P31749 | 1/20 | 0.55 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4656688 | 0.88 | BRAF (0.84) | BRAF | |
| SCHEMBL4763004 | 0.88 | BRAF (0.80) | MAPK13PIM1BRAFGSK3AEPHA2 | |
| SCHEMBL5808836 | 0.88 | BRAF (0.57) | MAPK13PIM1BRAFGSK3AEPHA2 | |
| SCHEMBL5807557 | 0.87 | CDKN1A (0.74) | MAPK13PIM1BRAFGSK3AEPHA2 | |
| SCHEMBL10733510 | 0.86 | GSK3A (0.59) | MAPK13PIM1BRAFGSK3AEPHA2 | |
| SCHEMBL7361381 | 0.84 | PIM1 (0.60) | MAPK13PIM1BRAFGSK3AEPHA2 | |
| SCHEMBL4657345 | 0.83 | GSK3A (0.59) | MAPK13PIM1BRAFGSK3AEPHA2 | |
| SCHEMBL5819944 | 0.83 | PIM1 (0.57) | MAPK13PIM1BRAFGSK3AEPHA2 | |
| SCHEMBL7363602 | 0.82 | MAPK13 (0.57) | MAPK13PIM1BRAFGSK3AEPHA2 | |
| SCHEMBL5823296 | 0.82 | BRAF (0.57) | MAPK13PIM1BRAFGSK3AEPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996594-A2 | PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007109093-A2 | PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |