Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | COMT | P21964 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4543897 | 0.84 | POLB (0.50) | POLBTDP1L3MBTL1APEX1KDM4E | |
| SCHEMBL4540551 | 0.84 | POLB (0.50) | POLBTDP1L3MBTL1APEX1KDM4E | |
| SCHEMBL17572311 | 0.78 | NPSR1 (0.47) | POLBKDM4EMAPTMEN1KMT2A | |
| SCHEMBL7630480 | 0.76 | RECQL (0.57) | POLBTDP1L3MBTL1APEX1KDM4E | |
| SCHEMBL29286704 | 0.74 | MAPT (0.42) | POLBTDP1L3MBTL1APEX1MAPT | |
| SCHEMBL14924781 | 0.74 | PTGS2 (0.46) | POLBKDM4EMAPTHTTCOMT | |
| SCHEMBL2069815 | 0.73 | KDM4E (0.47) | POLBTDP1L3MBTL1KDM4EMAPT | |
| SCHEMBL4626318 | 0.72 | POLB (0.47) | POLBTDP1L3MBTL1APEX1KDM4E | |
| SCHEMBL8306577 | 0.71 | NPSR1 (0.47) | POLBTDP1L3MBTL1KDM4EMAPT | |
| SCHEMBL4540024 | 0.71 | POLB (0.53) | POLBTDP1L3MBTL1APEX1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732541-A4 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL (JP) | 2008-03-05 | — | — | EP | disclosed |
| EP-1732541-A2 | CYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005099688-A2 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-10-27 | — | — | WO | disclosed |