Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 9/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.32 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.32 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646453 | 0.94 | HCAR2 (0.50) | HCAR2PYGLTSHREGLN1TP53 | |
| SCHEMBL3716837 | 0.94 | HCAR2 (0.50) | HCAR2PYGLTSHREGLN1TP53 | |
| SCHEMBL28120698 | 0.89 | HCAR2 (0.40) | HCAR2FOLH1PYGLKDM4EMAPT | |
| Fumaric Acid SCHEMBL3790173 | 0.86 | ACE (0.37) | HCAR2FOLH1TSHREGLN1TP53 | |
| Oxaloacetate SCHEMBL3490722 | 0.83 | HCAR2 (0.41) | HCAR2PYGL | |
| SCHEMBL9136836 | 0.83 | HCAR2 (0.41) | HCAR2PYGL | |
| Fumaric Acid SCHEMBL17871054 | 0.81 | ACE (0.35) | HCAR2FOLH1TSHREGLN1TP53 | |
| SCHEMBL26102844 | 0.78 | MMP1 (0.36) | HCAR2PYGLKDM4EMAPTHPGD | |
| SCHEMBL19119832 | 0.77 | HCAR2 (0.44) | HCAR2TSHREGLN1TP53EGLN3 | |
| SCHEMBL19107081 | 0.77 | HCAR2 (0.44) | HCAR2TSHREGLN1TP53EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838837-B1 | RECOMBINANT MICROORGANISMS FOR INCREASED PRODUCTION OF ORGANIC ACIDS | MICHIGAN BIOTECH INST (US) | 2015-04-15 | — | — | EP | disclosed |
| US-8431373-B2 | Recombinant microorganisms for increased production of organic acids | MICHIGAN BIOTECHNOLOGY INSTITUTE (US) | 2013-04-30 | — | — | US | disclosed |
| US-20120164703-A1 | RECOMBINANT MICROORGANISMS FOR INCREASED PRODUCTION OF ORGANIC ACIDS | MICHIGAN BIOTECHNOLOGY INSTITUTE (US) | 2012-06-28 | — | — | US | disclosed |
| EP-2460872-A1 | Recombinant microorganisms for increased production of organic acids | MICHIGAN BIOTECHNOLOGY INSTITUTE (US) | 2012-06-06 | — | — | EP | disclosed |
| US-8119377-B2 | Recombinant microorganisms for increased production of organic acids | MICHIGAN BIOTECHNOLOGY INSTITUTE (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2406389-A1 | METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS | Agios Pharmaceuticals, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010105243-A1 | METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS | AGIOS PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | WO | disclosed |
| US-20080305533-A1 | Recombinant Microorganisms For Increased Production of Organic Acids | ORACLE INTERNATIONAL CORPORATION (US) | 2008-12-11 | — | — | US | disclosed |