Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.48 |
| ▸ | KDM4A | O75164 | 2/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.48 |
| ▸ | TET3 | O43151 | 2/20 | 0.48 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL8799742 | 1.00 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL465926 | 1.00 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL17871055 | 0.94 | SMN1; SMN2 (0.58) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL17871053 | 0.94 | SMN1; SMN2 (0.58) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL9719878 | 0.93 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL646455 | 0.93 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL3061502 | 0.93 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL27302361 | 0.93 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL1533801 | 0.93 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL9719873 | 0.93 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2KDM4AKDM4CKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838837-B1 | RECOMBINANT MICROORGANISMS FOR INCREASED PRODUCTION OF ORGANIC ACIDS | MICHIGAN BIOTECH INST (US) | 2015-04-15 | — | — | EP | disclosed |
| US-8431373-B2 | Recombinant microorganisms for increased production of organic acids | MICHIGAN BIOTECHNOLOGY INSTITUTE (US) | 2013-04-30 | — | — | US | disclosed |
| US-20120164703-A1 | RECOMBINANT MICROORGANISMS FOR INCREASED PRODUCTION OF ORGANIC ACIDS | MICHIGAN BIOTECHNOLOGY INSTITUTE (US) | 2012-06-28 | — | — | US | disclosed |
| EP-2460872-A1 | Recombinant microorganisms for increased production of organic acids | MICHIGAN BIOTECHNOLOGY INSTITUTE (US) | 2012-06-06 | — | — | EP | disclosed |
| US-8119377-B2 | Recombinant microorganisms for increased production of organic acids | MICHIGAN BIOTECHNOLOGY INSTITUTE (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2406389-A1 | METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS | Agios Pharmaceuticals, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010109408-A1 | METHOD TO IMPROVE PHOSPHATE SOLUBILIZATION IN PLANTS | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010105243-A1 | METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS | AGIOS PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | WO | disclosed |
| US-20080305533-A1 | Recombinant Microorganisms For Increased Production of Organic Acids | ORACLE INTERNATIONAL CORPORATION (US) | 2008-12-11 | — | — | US | disclosed |
| EP-0525123-B1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | UPJOHN CO (US) | 1997-09-17 | — | — | EP | disclosed |