Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.44 |
| ▸ | TET3 | O43151 | 2/20 | 0.44 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.42 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL646455 | 1.00 | SMN1; SMN2 (0.75) | SMN1; SMN2TSHRTP53EGLN1EGLN3 | |
| Malic Acid SCHEMBL9719878 | 1.00 | SMN1; SMN2 (0.75) | SMN1; SMN2TSHRTP53EGLN1EGLN3 | |
| Malic Acid SCHEMBL27302361 | 1.00 | SMN1; SMN2 (0.75) | SMN1; SMN2TSHRTP53EGLN1EGLN3 | |
| Malic Acid SCHEMBL3061502 | 1.00 | SMN1; SMN2 (0.75) | SMN1; SMN2TSHRTP53EGLN1EGLN3 | |
| Malic Acid SCHEMBL1533801 | 1.00 | SMN1; SMN2 (0.75) | SMN1; SMN2TSHRTP53EGLN1EGLN3 | |
| Malic Acid SCHEMBL969854 | 0.98 | SMN1; SMN2 (0.71) | SMN1; SMN2TSHRTP53EGLN1EGLN3 | |
| Malic Acid SCHEMBL969848 | 0.98 | SMN1; SMN2 (0.71) | SMN1; SMN2TSHRTP53EGLN1EGLN3 | |
| Malic Acid SCHEMBL27560921 | 0.95 | SMN1; SMN2 (0.68) | SMN1; SMN2TSHRTP53EGLN1EGLN3 | |
| Malic Acid SCHEMBL465928 | 0.93 | SMN1; SMN2 (0.65) | SMN1; SMN2TSHRTP53EGLN1EGLN3 | |
| Malic Acid SCHEMBL465926 | 0.93 | SMN1; SMN2 (0.65) | SMN1; SMN2TSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5171886-A | Michael condensation of salts of maleic and malic acids in presence of calcium ion catalyst; reacting and reuse of by-products; hydration of sodium hydrogen maleate; detergent builders | MONSANTO COMPANY (US) | 1992-12-15 | — | — | US | disclosed |