Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | TACR2 | P21452 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | TSPO | P30536 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL605123 | 0.85 | OPRM1 (0.54) | OPRM1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4745949 | 0.85 | OPRM1 (0.64) | OPRM1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL13243484 | 0.84 | CHRM1 (0.61) | OPRM1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4648973 | 0.81 | CHRM1 (0.49) | OPRM1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4649387 | 0.80 | CHRM1 (0.46) | OPRM1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4646443 | 0.80 | OPRM1 (0.48) | OPRM1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4648241 | 0.79 | CHRM2 (0.56) | OPRM1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4636638 | 0.79 | CHRM2 (0.66) | OPRM1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4648437 | 0.79 | OPRM1 (0.50) | OPRM1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2998510 | 0.79 | OPRM1 (0.51) | OPRM1CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004182-A1 | BENZIMIDAZOLES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007107565-A1 | BENZIMIDAZOLES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-09-27 | — | — | WO | disclosed |