Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.76 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.76 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.60 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.60 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.60 |
| ▸ | LTA4H | P09960 | 1/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GCGR | P47871 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | EBP | Q15125 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6595870 | 0.96 | ESR1 (0.83) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL11179589 | 0.96 | ESR1 (0.83) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL4660156 | 0.96 | ESR1 (0.79) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL4651968 | 0.95 | ESR1 (0.70) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL4650720 | 0.95 | ESR1 (0.70) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL4651846 | 0.95 | ESR1 (0.81) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL11176566 | 0.94 | ESR1 (0.69) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| Trioxifene SCHEMBL29464170 | 0.94 | ESR1 (0.69) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| Trioxifene SCHEMBL4651963 | 0.94 | ESR1 (0.69) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL11180048 | 0.94 | ESR1 (0.69) | ESR1ESR2PSMB1PSMB5PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863755-B1 | ANTITHROMBOTIC DIAMINES | LILLY CO ELI (US) | 2004-12-15 | — | — | EP | disclosed |
| US-6265575-B1 | THROMBIN INHIBITORS | ELI LILLY AND COMPANY | 2001-07-24 | — | — | US | disclosed |
| US-6251921-B1 | ADMINISTERING THROMBIN INHIBITING DIAMINE COMPOUND TO MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-6025382-A | Antithrombotic diamines | ELI LILLY AND COMPANY (US) | 2000-02-15 | — | — | US | disclosed |
| EP-0863755-A4 | ANTITHROMBOTIC DIAMINES | LILLY CO ELI (US) | 1999-01-20 | — | — | EP | disclosed |
| EP-0863755-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997025033-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1997-07-17 | — | — | WO | disclosed |