Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 19/20 | 0.62 |
| ▸ | HTR2C | P28335 | 18/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4660602 | 0.91 | HTR2A (0.60) | HTR2AHTR2C | |
| SCHEMBL4838138 | 0.89 | HTR2A (0.55) | HTR2AHTR2CSMN1; SMN2 | |
| SCHEMBL4660554 | 0.88 | HTR2A (0.59) | HTR2AHTR2C | |
| SCHEMBL4659283 | 0.84 | HTR2A (0.58) | HTR2AHTR2C | |
| SCHEMBL4724168 | 0.83 | HTR2A (0.61) | HTR2AHTR2CSMN1; SMN2 | |
| SCHEMBL4660702 | 0.81 | HTR2A (0.52) | HTR2AHTR2CSMN1; SMN2 | |
| SCHEMBL4659250 | 0.80 | HTR2A (0.66) | HTR2AHTR2C | |
| SCHEMBL4660682 | 0.80 | HTR2A (0.76) | HTR2AHTR2C | |
| SCHEMBL4659253 | 0.80 | HTR2A (0.58) | HTR2AHTR2CSMN1; SMN2 | |
| SCHEMBL884284 | 0.78 | HTR2A (0.64) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004627-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120600-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007120600-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |