Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.60 |
| ▸ | HTR2C | P28335 | 6/20 | 0.60 |
| ▸ | RAF1 | P04049 | 7/20 | 0.54 |
| ▸ | BRAF | P15056 | 7/20 | 0.54 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.50 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.50 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.50 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4660446 | 0.91 | HTR2A (0.62) | HTR2AHTR2C | |
| SCHEMBL4659250 | 0.90 | HTR2A (0.66) | HTR2AHTR2CRAF1BRAFKCNQ3 | |
| SCHEMBL4659283 | 0.88 | HTR2A (0.58) | HTR2AHTR2CKCNQ3KCNQ2KCNE1 | |
| SCHEMBL4660700 | 0.88 | HTR2A (0.56) | HTR2AHTR2CRAF1BRAFKCNQ3 | |
| SCHEMBL4660549 | 0.84 | HTR2A (0.63) | HTR2AHTR2CRAF1BRAF | |
| SCHEMBL4660554 | 0.81 | HTR2A (0.59) | HTR2AHTR2C | |
| SCHEMBL4838138 | 0.81 | HTR2A (0.55) | HTR2AHTR2CRAF1BRAFKCNQ3 | |
| SCHEMBL884318 | 0.80 | HTR2A (0.62) | HTR2AHTR2C | |
| SCHEMBL1166495 | 0.78 | HTR2A (0.74) | HTR2AHTR2C | |
| SCHEMBL4660486 | 0.78 | HTR2A (0.76) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004627-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | claimed |
| WO-2007120600-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | claimed |
| EP-2004627-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120600-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007120600-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |