Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 16/20 | 0.39 |
| ▸ | HTR2C | P28335 | 16/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4661846 | 0.82 | HTR2A (0.39) | HTR2AHTR2CCHEK1DAPK3GRK5 | |
| SCHEMBL4660440 | 0.76 | MAPT (0.43) | CHEK1DAPK3GRK5LIMK1ALDH1A1 | |
| SCHEMBL5946668 | 0.75 | CYP19A1 (0.46) | HTR2AHTR2CCHEK1DAPK3GRK5 | |
| SCHEMBL5578067 | 0.74 | HTR2A (0.55) | HTR2AHTR2C | |
| SCHEMBL5578120 | 0.74 | HTR2A (0.55) | HTR2AHTR2CALDH1A1MEN1MAPT | |
| SCHEMBL2405141 | 0.73 | ALDH1A1 (0.47) | ALDH1A1MEN1MAPTHPGDKMT2A | |
| SCHEMBL1167056 | 0.72 | HTR2A (0.44) | HTR2AHTR2C | |
| SCHEMBL4768514 | 0.72 | HTR2A (0.49) | HTR2AHTR2CALDH1A1RAB9AMEN1 | |
| SCHEMBL4794432 | 0.72 | HTR2A (0.36) | HTR2AHTR2CCHEK1DAPK3GRK5 | |
| SCHEMBL5578020 | 0.72 | HTR2A (0.55) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004627-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120600-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |