Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 16/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CDK7 | P50613 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
| ▸ | WNT1 | P04628 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4661028 | 0.93 | AKT1 (0.52) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL5469830 | 0.91 | AKT1 (0.51) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL4660913 | 0.91 | AKT1 (0.58) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL4659655 | 0.90 | AKT1 (0.48) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL5472198 | 0.85 | AKT1 (0.48) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL4658643 | 0.85 | AKT1 (0.75) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL4659746 | 0.83 | AKT1 (0.58) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL5467193 | 0.83 | AKT1 (0.44) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL14430184 | 0.83 | AKT1 (0.44) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL14430135 | 0.83 | AKT1 (0.48) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720855-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2008-12-17 | — | — | EP | disclosed |
| EP-1720855-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005085227-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-15 | — | — | WO | disclosed |