Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 16/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CDK7 | P50613 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
| ▸ | PRKACB | P22694 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5472198 | 0.94 | AKT1 (0.48) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL14430184 | 0.92 | AKT1 (0.44) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL14430135 | 0.92 | AKT1 (0.48) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL4660760 | 0.91 | AKT1 (0.56) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL5467193 | 0.91 | AKT1 (0.44) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL14430153 | 0.89 | HDAC3 (0.52) | AKT1ROCK1CDK2CDK7PRKACA | |
| SCHEMBL14430179 | 0.89 | AKT1 (0.42) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL6855907 | 0.86 | HDAC3 (0.42) | AKT1CDK2CDK7MAPK1ATM | |
| SCHEMBL6855905 | 0.86 | HDAC3 (0.42) | AKT1CDK2CDK7MAPK1ATM | |
| SCHEMBL4658726 | 0.86 | AKT1 (0.44) | AKT1ROCK1CSNK1A1CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185152-A1 | Inhibitors of akt activity | SMITHKLINE BEECHAM CORPORATION | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185152-A1 | Inhibitors of akt activity | AKT1, AKT1S1, AKT2 | AKT1 1/4885ROCK1 589/4885CSNK1A1 545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.