Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727593 | 0.86 | KDM4E (0.41) | KDM4EPOLBRECQLMAPTABL1 | |
| SCHEMBL4659621 | 0.76 | LPAR1 (0.42) | KDM4EHSD17B10ALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL4662315 | 0.73 | PTGDR2 (0.40) | KDM4EPOLBRECQLMAPTABL1 | |
| SCHEMBL4659631 | 0.65 | KDM4E (0.61) | KDM4ERECQLMAPTHSD17B10ALDH1A1 | |
| SCHEMBL4305121 | 0.64 | CYP1A2 (0.50) | KDM4EPOLBHSD17B10ALDH1A1TSHR | |
| SCHEMBL8463727 | 0.60 | HSD17B10 (0.56) | KDM4EPOLBRECQLMAPTABL1 | |
| SCHEMBL12477951 | 0.60 | POLB (0.59) | KDM4EPOLBRECQLMAPTABL1 | |
| SCHEMBL8464523 | 0.57 | HSD17B10 (0.56) | KDM4EPOLBRECQLMAPTABL1 | |
| SCHEMBL4308637 | 0.57 | CYP1A2 (0.52) | KDM4EPOLBHSD17B10ALDH1A1TSHR | |
| SCHEMBL509824 | 0.57 | HSD17B10 (0.54) | KDM4EPOLBRECQLMAPTABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004193-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007108968-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2007-09-27 | — | — | WO | disclosed |