Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4660837 | 0.86 | KDM4E (0.36) | KDM4EMAPTPOLBABL1RECQL | |
| SCHEMBL3430749 | 0.78 | GAA (0.43) | KDM4EHSD17B10GAAGRIN2DGRIN3B | |
| SCHEMBL4662315 | 0.77 | PTGDR2 (0.40) | KDM4EMAPTPOLBABL1RECQL | |
| SCHEMBL3353013 | 0.77 | DHODH (0.45) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL4659621 | 0.74 | LPAR1 (0.42) | KDM4EHSD17B10ALDH1A1SMN1; SMN2AKR1C2 | |
| SCHEMBL4659631 | 0.70 | KDM4E (0.61) | KDM4EMAPTRECQLHSD17B10ALDH1A1 | |
| SCHEMBL4308637 | 0.70 | CYP1A2 (0.52) | KDM4EPOLBHSD17B10ALDH1A1TSHR | |
| SCHEMBL3346086 | 0.68 | PTGER4 (0.44) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3431673 | 0.68 | HSD17B10 (0.41) | KDM4EMAPTPOLBHSD17B10ALDH1A1 | |
| SCHEMBL4310456 | 0.67 | ALDH1A1 (0.54) | KDM4EMAPTPOLBHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008030390-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2008-03-13 | — | — | WO | claimed |
| WO-2008030390-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2008-03-13 | — | — | WO | disclosed |