Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | SI | P14410 | 1/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15359356 | 0.84 | GAA (0.50) | GAAMGAMSIMGAM2L3MBTL1 | |
| SCHEMBL5571264 | 0.81 | KMT2A (0.52) | GAAMGAMSIMGAM2L3MBTL1 | |
| SCHEMBL3220536 | 0.81 | GAA (0.56) | GAAMGAMSIMGAM2L3MBTL1 | |
| SCHEMBL10890026 | 0.81 | GAA (0.44) | GAACYP1A2MAPTCYP3A4CYP2D6 | |
| SCHEMBL5411533 | 0.79 | GAA (0.48) | GAAMGAMSIMGAM2L3MBTL1 | |
| SCHEMBL5411539 | 0.79 | GAA (0.48) | GAAMGAMSIMGAM2L3MBTL1 | |
| SCHEMBL4432951 | 0.79 | GAA (0.48) | GAAMGAMSIMGAM2L3MBTL1 | |
| SCHEMBL15726347 | 0.79 | CASP2 (0.52) | GAAMGAMSIMGAM2L3MBTL1 | |
| SCHEMBL22971258 | 0.79 | GAA (0.45) | GAAMGAMSIMGAM2L3MBTL1 | |
| SCHEMBL10259138 | 0.78 | GAA (0.47) | GAAMGAMSIMGAM2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004193-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007108968-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2007-09-27 | — | — | WO | disclosed |