Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 6/20 | 0.83 |
| ▸ | RORC | P51449 | 5/20 | 0.83 |
| ▸ | OSBP2 | Q969R2 | 3/20 | 0.83 |
| ▸ | USP2 | O75604 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 1/20 | 0.83 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.83 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.83 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.71 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.71 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.71 |
| ▸ | CRYAB | P02511 | 1/20 | 0.68 |
| ▸ | HMGCR | P04035 | 1/20 | 0.68 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.68 |
| ▸ | ITGAV | P06756 | 1/20 | 0.68 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.68 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.68 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | F2 | P00734 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL3209056 | 1.00 | OSBP (0.83) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL3209061 | 1.00 | OSBP (0.83) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL28419656 | 1.00 | OSBP (0.83) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL4661901 | 1.00 | OSBP (0.83) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL28077325 | 0.98 | OSBP (0.83) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27651839 | 0.97 | OSBP (0.78) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL28097544 | 0.97 | OSBP (0.89) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27624441 | 0.96 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27968992 | 0.95 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL18049020 | 0.93 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212339-B1 | 2'-O-ACETAMIDO MODIFIED MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS INC (US) | 2008-12-31 | — | — | EP | disclosed |
| EP-1212339-A4 | 2'-O-ACETAMIDO MODIFIED MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS INC (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1212339-A1 | 2'-O-ACETAMIDO MODIFIED MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS, INC. (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014400-A1 | 2'-O-ACETAMIDO MODIFIED MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS, INC. (US) | 2001-03-01 | — | — | WO | disclosed |
| US-6147200-A | NUCLEOSIDES FOR SOLID PHASE SYNTHESIS OF OLIGONUCLEOTIDES HAVING INCREASED NUCLEASE RESISTANCE AND BETTER BINDING AFFINITY; DIAGNOSIS; ANTISENSE THERAPY | ISIS PHARMACEUTICALS, INC. (US) | 2000-11-14 | — | — | US | disclosed |