Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4663158 | 0.87 | LMNA (0.38) | LMNAHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL4662028 | 0.79 | — | — | |
| SCHEMBL1636664 | 0.72 | CYP2C9 (0.37) | LMNAHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL1634966 | 0.72 | CYP2C9 (0.37) | LMNAHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL1634488 | 0.72 | CYP2C9 (0.37) | LMNAHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL1633726 | 0.72 | CYP2C9 (0.37) | LMNAHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL1634696 | 0.72 | CYP2C9 (0.37) | LMNAHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL1634885 | 0.72 | LMNA (0.44) | LMNAHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL1635905 | 0.72 | LMNA (0.44) | LMNAHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL1635257 | 0.70 | MME (0.42) | LMNAHPGDALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558230-B1 | SPIROCYCLOPROPYL AMIDES AND ACIDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LAB (US) | 2008-12-31 | — | — | EP | claimed |