Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068123 | 0.75 | — | — | |
| SCHEMBL4661991 | 0.75 | — | — | |
| SCHEMBL4662128 | 0.74 | CYP2C19 (0.32) | ALDH1A1CYP2C19 | |
| SCHEMBL4660714 | 0.74 | CYP2C19 (0.32) | ALDH1A1CYP2C19 | |
| SCHEMBL4661900 | 0.74 | CYP2C19 (0.32) | ALDH1A1CYP2C19 | |
| SCHEMBL4661890 | 0.74 | CYP2C19 (0.32) | ALDH1A1CYP2C19 | |
| SCHEMBL4660712 | 0.74 | CYP2C19 (0.32) | ALDH1A1CYP2C19 | |
| SCHEMBL1636177 | 0.73 | SLC1A2 (0.33) | EPHX1KDM4EGAAALDH1A1LMNA | |
| SCHEMBL28199763 | 0.70 | MAPT (0.51) | MAPTAPOBEC3AAPOBEC3GEPHX1KDM4E | |
| SCHEMBL20483727 | 0.69 | EPHX1 (0.33) | MAPTAPOBEC3AAPOBEC3GEPHX1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558230-B1 | SPIROCYCLOPROPYL AMIDES AND ACIDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LAB (US) | 2008-12-31 | — | — | EP | claimed |