Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | SHBG | P04278 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL780298 | 0.78 | NPC1 (0.48) | SMN1; SMN2RAB9AMEN1NPC1MAPT | |
| SCHEMBL9686869 | 0.76 | SMN1; SMN2 (0.41) | SMN1; SMN2RAB9AMEN1NPC1MAPT | |
| SCHEMBL186541 | 0.76 | CNR1 (0.42) | SMN1; SMN2RAB9AMEN1NPC1MAPT | |
| SCHEMBL13539167 | 0.76 | SMN1; SMN2 (0.37) | SMN1; SMN2RAB9AMEN1NPC1MAPT | |
| SCHEMBL1619364 | 0.76 | TAAR1 (0.60) | SMN1; SMN2RAB9AMEN1NPC1MAPT | |
| SCHEMBL1720942 | 0.75 | TAAR1 (0.58) | MAPTMAPK1KMT2AKCNN4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8508349 | 0.74 | TAAR1 (0.58) | SMN1; SMN2RAB9AMEN1NPC1MAPT | |
| SCHEMBL19232109 | 0.74 | CNR2 (0.42) | SMN1; SMN2RAB9AMEN1NPC1MAPT | |
| SCHEMBL8325626 | 0.74 | KCNN4 (0.43) | SMN1; SMN2MEN1MAPK1HTTKMT2A | |
| SCHEMBL1721847 | 0.73 | KCNN4 (0.37) | SMN1; SMN2RAB9AMEN1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682105-A4 | N-UREIDOALKYL-AMINO COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2008-12-24 | — | — | EP | disclosed |
| EP-1682105-A2 | N-UREIDOALKYL-AMINO COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005048932-A2 | N-UREIDOALKYL-AMINO COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-06-02 | — | — | WO | disclosed |