Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.45 |
| ▸ | SLC16A3 | O15427 | 13/20 | 0.41 |
| ▸ | SLC16A1 | P53985 | 12/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MARS1 | P56192 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3473117 | 0.84 | RXRA (0.64) | RXRANR1H2NR1H3SLC16A3SLC16A1 | |
| SCHEMBL4662711 | 0.82 | RXRA (0.47) | RXRANR1H2NR1H3SLC16A3SLC16A1 | |
| SCHEMBL3472578 | 0.76 | RXRA (0.75) | RXRANR1H2NR1H3SLC16A3SLC16A1 | |
| SCHEMBL4663234 | 0.75 | RXRA (0.46) | RXRANR1H2NR1H3SLC16A3SLC16A1 | |
| SCHEMBL3473121 | 0.73 | RXRA (0.68) | RXRANR1H2NR1H3RORCKDM4E | |
| SCHEMBL3473130 | 0.72 | RXRA (0.66) | RXRANR1H2NR1H3SLC16A3SLC16A1 | |
| SCHEMBL3471768 | 0.72 | RXRA (0.65) | RXRANR1H2NR1H3 | |
| SCHEMBL3473580 | 0.71 | RXRA (0.68) | RXRANR1H2NR1H3SLC16A3SLC16A1 | |
| SCHEMBL3472456 | 0.71 | RXRA (0.62) | RXRANR1H2NR1H3 | |
| SCHEMBL3473229 | 0.71 | RXRA (0.69) | RXRANR1H2NR1H3SLC16A3SLC16A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910307-A1 | PYRAZOLE BASED LXR MODULATORS | Exelixis, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007002559-A1 | PYRAZOLE BASED LXR MODULATORS | EXELIXIS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |