Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PTPRZ1 | P23471 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727739 | 0.85 | PDE2A (0.54) | ALDH1A1SLC6A2SLC6A4SLC6A3PDE2A | |
| SCHEMBL2021163 | 0.85 | PDE2A (0.54) | ALDH1A1SLC6A2SLC6A4SLC6A3PDE2A | |
| SCHEMBL1729345 | 0.85 | PDE2A (0.54) | ALDH1A1SLC6A2SLC6A4SLC6A3PDE2A | |
| Hydrochloric Acid SCHEMBL2716505 | 0.84 | PDE2A (0.53) | ALDH1A1SLC6A2SLC6A4SLC6A3PDE2A | |
| Hydrochloric Acid SCHEMBL14120857 | 0.84 | PDE2A (0.53) | ALDH1A1SLC6A2SLC6A4SLC6A3PDE2A | |
| Hydrochloric Acid SCHEMBL20302874 | 0.84 | PDE2A (0.53) | ALDH1A1SLC6A2SLC6A4SLC6A3PDE2A | |
| SCHEMBL14163891 | 0.80 | RXRA (0.56) | MAOBMRGPRX4RXRARXRBMMP1 | |
| SCHEMBL5921896 | 0.79 | MAOB (0.70) | MAOBMRGPRX4MMP1MMP2MMP9 | |
| SCHEMBL6376299 | 0.79 | MAOB (0.59) | MAOBSLC6A2SLC6A3 | |
| SCHEMBL14437997 | 0.79 | MAOB (0.54) | MAOBMRGPRX4MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008487-B2 | Substituted thieno[2,3-D]pyrimidines as fungicides | DOW AGROSCIENCES LLC (US) | 2011-08-30 | — | — | US | disclosed |
| US-8008487-B2 | Substituted thieno[2,3-D]pyrimidines as fungicides | DOW AGROSCIENCES LLC (US) | 2011-08-30 | — | — | US | disclosed |
| US-7423060-B2 | Thiophene hydroxamic acid derivatives and their use as HDAC inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2008-09-09 | — | — | US | disclosed |
| US-20080070976-A1 | Thiophene Hydroxamic Acid Derivatives and Their Use as Hdac Inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | US | disclosed |
| CN-1964962-A | Thiophene hydroxamic acid derivatives and their use as HDAC inhibitors | HOFFMANN LA ROCHE (CH) | 2007-05-16 | — | — | CN | disclosed |
| EP-1758881-A1 | THIOPHENE HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HDAC INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005121120-A1 | THIOPHENE HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HDAC INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070976-A1 | Thiophene Hydroxamic Acid Derivatives and Their Use as Hdac Inhibitors | HDAC1, HDAC5, HDAC2 | MAOB 1022/4885MRGPRX4 4650/4885RXRA 844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.