Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 2/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22317120 | 0.84 | VHL (0.49) | VHLHCAR2MEN1KMT2AEPHX2 | |
| SCHEMBL1698651 | 0.81 | VHL (0.58) | VHLHCAR2MEN1KMT2AEPHX2 | |
| SCHEMBL12530275 | 0.81 | VHL (0.46) | VHLHCAR2MEN1KMT2AEPHX2 | |
| SCHEMBL2402699 | 0.80 | MMP2 (0.36) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL22317122 | 0.79 | VHL (0.49) | VHLHCAR2MEN1KMT2AEPHX2 | |
| SCHEMBL3123403 | 0.79 | MMP2 (0.39) | MEN1KMT2ASMN1; SMN2RAB9ATP53 | |
| SCHEMBL28611482 | 0.77 | PPARA (0.56) | VHLHCAR2MEN1KMT2AEPHX2 | |
| SCHEMBL20320540 | 0.76 | VHL (0.41) | VHLHCAR2MEN1KMT2AEPHX2 | |
| SCHEMBL12753495 | 0.76 | VHL (0.42) | VHLHCAR2MEN1KMT2AEPHX2 | |
| SCHEMBL4694487 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007717-A1 | NOVEL SULFONAMIDE COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007116374-A1 | NOVEL SULFONAMIDE COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-10-18 | — | — | WO | disclosed |