Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 6/20 | 0.44 |
| ▸ | JAK1 | P23458 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 4/20 | 0.41 |
| ▸ | BCR | P11274 | 4/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL4663884 | 0.92 | ABL1 (0.43) | JAK2PIK3CGPIK3R1PIK3CAPIK3CB | |
| Formic Acid SCHEMBL4663746 | 0.92 | PIK3CA (0.48) | JAK2PIK3CGPIK3R1PIK3CAPIK3CB | |
| Formic Acid SCHEMBL4664337 | 0.91 | ABL1 (0.42) | JAK2PIK3CGPIK3R1PIK3CAPIK3CB | |
| Formic Acid SCHEMBL4665756 | 0.84 | JAK1 (0.43) | JAK2PIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL4663917 | 0.83 | ABL1 (0.48) | JAK2JAK3JAK1NPC1RAB9A | |
| SCHEMBL4664264 | 0.83 | JAK2 (0.41) | JAK2JAK3JAK1NPC1RAB9A | |
| SCHEMBL4665820 | 0.83 | ABL1 (0.48) | ABL1BCREGFR | |
| Formic Acid SCHEMBL4664276 | 0.83 | PIK3CA (0.44) | JAK2PIK3CGPIK3R1PIK3CAPIK3CB | |
| Formic Acid SCHEMBL4666178 | 0.82 | ABL1 (0.44) | JAK2JAK3JAK1ABL1BCR | |
| Formic Acid SCHEMBL4665878 | 0.81 | ABL1 (0.45) | JAK2JAK3KMT2AMAPTABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242681-A1 | N-4-(6-(Hetero)Aryl-Pyrimidin-4-Ylaminophenyl)-Benzenesulfonamides as Kinase Inhibitors | ALTANA PHARMA AG (DE) | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242681-A1 | N-4-(6-(Hetero)Aryl-Pyrimidin-4-Ylaminophenyl)-Benzenesulfonamides as Kinase Inhibitors | MAP3K19, MAP3K6, MAP3K20 | JAK2 63/4885PIK3CG 440/4885PIK3R1 385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.