Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 14/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9314358 | 0.76 | KMT2A (0.66) | MEN1KMT2AACHE | |
| SCHEMBL28519082 | 0.75 | MEN1 (0.56) | MEN1KMT2AACHETAAR1 | |
| SCHEMBL28519083 | 0.75 | MEN1 (0.56) | MEN1KMT2AACHETAAR1 | |
| SCHEMBL2723540 | 0.74 | KMT2A (0.68) | MEN1KMT2AACHE | |
| SCHEMBL27526614 | 0.74 | KMT2A (0.68) | MEN1KMT2AACHEMAOB | |
| SCHEMBL2851334 | 0.74 | FOLH1 (0.54) | — | |
| SCHEMBL2859259 | 0.73 | SLC7A5 (0.60) | MEN1KMT2A | |
| SCHEMBL3827847 | 0.73 | KMT2A (0.53) | MEN1KMT2AACHETAAR1MAOA | |
| SCHEMBL14783795 | 0.73 | MEN1 (0.61) | MEN1KMT2AACHETAAR1 | |
| SCHEMBL2721243 | 0.72 | KMT2A (0.66) | MEN1KMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007737-A2 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007113558-A2 | QUINAZOLINONE DERIVATIVES HAVING B-RAF INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |